On February 8, 1892, Virginia Anna Betts, a 24-year-old white female residing in Chicago, Illinois, died under circumstances later linked to H. H. Holmes, one of America's earliest known serial killers. Holmes, born Herman Webster Mudgett, was a trained physician and pharmacist who operated a drugstore near his infamous "Murder Castle" in Chicago. In his 1896 confession, Holmes admitted to killing Anna Betts by substituting poison for her prescribed medication. His motive was disturbingly detach
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