Andre Lee Jeffery, Sr., 46, a man from Chicago, was shot on the afternoon of May 24, 2025, while behind the wheel in the 800 block of North Sacramento Avenue in the Humboldt Park neighborhood. The single shot struck his head as he drove; his vehicle kept moving, ramming into a parked car and then a light pole before coming to a stop. He was rushed to Mount Sinai Hospital in critical condition and was pronounced dead later that night at 10:30 p.m.
An autopsy the following day determined he died from a gunshot wound to the head, and the death was ruled a homicide.
Authorities identified Andre Lee Jeffery, Sr., 46, as the victim and recorded his date of death as May 24, 2025, in Chicago, Illinois. Public victim registries that track gun violence corroborate his identity, age, and date, placing him among those killed by gunfire that day.
Police said the shooting happened around 4:10 p.m. while Andre Lee Jeffery, Sr., 46, was driving, and they noted the immediate aftermath—the crash into the parked car and light pole—as part of the incident scene description. Detectives opened a homicide investigation following the medical examiner's ruling. As of the initial reports, no arrests had been made, and Area 1 detectives were handling the case.
Subsequent case-aggregation pages that compile official and media updates list Andre Lee Jeffery, Sr., 46, as male and echo that no suspect information or arrests were available in the immediate aftermath. They reference the same location details and confirm that the investigation remained active, with police seeking leads.
